Dermatosis model

Dermatosis model



Disease model

Modeling approach

Animal strains

Measurements

Scalded rabbit model

Boiling water or hot water immersion

New Zealand white rabbit

Morphological observation of skin burns; Histopathological   analysis of skin;

Scalded rat model

SD/Wistar   rat

Atopic dermatitis (atopic eczema) rat model

2,4-DNFBis   applied to the skin at the shaving site

SD/Wistar rat

The   changes of skin thickness and morphology were observed by HE staining

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Case analysis   Atopic dermatitis mouse model (Eczema mouse model)

Atopic dermatitis (AD), also known as atopic eczema, is a type of inflammation of the skin affecting 15-30% children and 2-10% adults world-wide. It results in itchy, red, swollen, and cracked skin. Clear fluid may come from the affected areas, which often thickens over time. This complex disorder features hypersensitivity to environmental agents and immune dysfunction, Yet, the sequential events leading to eczematous lesions are not completely understood. Therefore, in-depth study of the pathogenesis of atopic eczema is of great significance for the clinical search for effective treatment methods.

Experimental animal information

Name   of animal model

Atopic dermatitis rat model

Species and strains of animal

SD/   Wistar rat

Gender of animal

Age of animal

adult

Weight of animal

180~220g


Measurements

Morphological and pathological examination of skin lesions.

Partial result display

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HE stain(×200