| Tumor model
TOPBIOTECH tumor modeling technology include heterogenous, in situ and metastatic tumor model, and can use small animal living bioluminescence imaging system for in situ tumor and metastatic tumor research, according to the needs of customers, flexibly to develop and build a variety of customized models.
Tumor model | Modeling approach | Measurements | Xenograft tumor model | Subcutaneous injection/implant | Animal Characterization (weight/status/survival rate/drug toxicity, etc.) Pathological analysis(HE/IHC, etc.) Biochemical analysis (blood/body fluid/tissue) Molecular biology analysis (sequencing /biomarker analysis) Anatomic analysis imaging in vivo and so on | In situ xenograft tumor model | The inoculation site was consistent with the cell or tumor origin site | Metastatic xenograft model | Tail vein injection metastasis/in situ or ectopic inoculation metastasis |
Case analysis Xenograft model of colorectal cancer
Each mouse was inoculated subcutaneously into the armpits with human colorectal cancer cell line, The results showed the shape and size of subcutaneous tumors, and tumor growth was effectively controlled after administration.
Tumor types | Cell line | Head and neck cancer | FaDu, CAL-27 | Oral cancer | HSC-3, SCC-4, KB | Lung cancer | A549,NCH-H358,NCH-H460,NCH-H526,NCH-H1299,NCH-H1650,NCH-H1688, NCH-H1975, 95-D, PC-10, Calu-3 | Breast carcinoma | MDA-MB-231, MDA-MB-468, MDA-MB-453, HCC70, HCC1954, MDA-MB-361, MCF-7, BT474, BT549, SK-BR-3 | Gastric cancer | MKN-28,MKN-45, BGC-823,HGC-27,MKN-28,SCH, SGC-7901, SNU-5, SNU-16, MGC-803, AGS | Liver cancer | Hep-3B,Huh-7,PLC/PRF/5,QGY-7703,SK-HEP-1,SMMC-7721,HepG-2,BEL-7402, BEL-7404, MHCC97H, LM3 | Pancreatic cancer | AsPC-1, B×PC-3, Capan-1, Capan-2, CFPAC-1, MIAPaCa-2, PANC-1 | Renal cancer | ACHN, A498, 786-O, OS-RC-2 | Colorectal cancer | COLO 201, COLO 205, DLD-1, HCT-116, HT-29, LoVo, LS1034, LS174T, Caco2, RKO, SW480, SW620, SW1116, SW948 | Prostatic cancer | Du145, PC-3, LNCap, CL-1,C4-2 | Bladder cancer | HT-1376, RT4, SW780, T24, UM-UC-3, 5637, EJ | Ovarian cancer | ES-2, HO-8910PM, SK-OV-3, OVCAR-3, CAOV3, OV2008, 3-AO | cervical cancer | SiHa, Hela, Ca Ski, C33A | Melanoma | A375, A2058, C32, HMCB, SK-MEL-30 | Leukemia/ lymphoma | U937, THP-1, HEL, HL-60, K562, Kasumi-1, Jurkat, NB4, Raji, ARH-77, KMS-12-BM, KG-1, CML-T1, MOLM-13, MoLT-4, CCRF-CEM | Glioma | A172, U87-MG, U251, U343MG, U373, SW1783 |
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