Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease with unknown etiology, mainly involving central nervous system proteins. Its pathological features include perivascular inflammatory lesions, myelin sheath destruction, proliferation of astrocytes, loss of oligodendrocytes and axons. Experimental autoimmune encephalomyelitis (EAE) is currently internationally recognized as an animal model for studying MS. The most commonly used allergens are brain or spinal cord tissue homogenate, myelin protein components, or their peptide fragments. Due to the presence of Myelin oligodendrocyte glycoprotein (MOG) in the outermost layer of myelin and oligodendrocytes, which has high immunogenicity, MOG and anti MOG antibodies play an important role in the pathogenesis of MS. MOG induced EAE can be used as an ideal model for studying MS.

Observation indicators

Neurological function score and histopathological examination

Partial Results Display