Rheumatoid arthritis (RA) is a systemic autoimmune disease with unknown causes and multiple occurrences. Its basic pathological changes mainly include chronic synovial inflammation and destruction of articular cartilage and bone. Its clinical features include inflammation and swelling of joint structures, chronic progressive disease, and so on. It is of great significance to conduct research on the treatment of RA by establishing animal models.

Observation indicators

Ankle joint and toe area are red and swollen, which can invade the foot pad and the entire foot; The expression levels of inflammatory factors such as TNF-a, IL-2, IL-6, and IL-1 in serum are relatively high; The pathological manifestation is inflammation around the joints and soft tissues, which can cause synovial hyperplasia, cartilage damage, etc.

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