In 1983, Australian scholars Warren and Marshall first isolated Helicobacter pylori (H. pylori) from human gastric mucosa, which is a plasmid free Gram negative bacterium capable of producing toxins. This bacterium can cause inflammation and immune reactions in the body, disrupt the gastric mucosal barrier, and cause gastritis. Mice have a small body size and strong reproductive ability, making them the preferred host for establishing this model.

Observation indicators

Serum H Positive detection of pylori antibodies, rapid urease test, and detection of Helicobacter pylori; There is varying degrees of chronic inflammatory cell infiltration and glandular atrophy in the mucosal layer.

Partial Results Display